Trimethylsilyl Chloride

Basic Information of Trimethylsilyl Chloride

CAS No.:	75-77-4
EC No.:	200-900-5
Linear Formula:	(CH₃)₃SiCl
Molecular Weight:	108.64
Appearance:	Clear, colorless, fuming liquid.
Odor:	Pungent odor.
Melting Point:	−40 °C(lit.)
Boiling point:	57 °C(lit.)
Density:	0.857 g/mL at 25 °C
Reactivity:	Reacts vigorously with water (hydrolyzes to hexamethyldisiloxane and hydrochloric acid), alcohols, amines, and other protic solvents.
Flammability:	Flammable liquid and vapor.
Corrosivity:	Corrosive to metals in the presence of moisture and to organic tissues.
RIDADR:	UN 1298 3/PG 2
Chemical Structure:

Our commitment to delivering high-purity Trimethylsilyl Chloride ensures a reliable and efficient component for your critical processes, offering consistent quality for diverse industrial needs, while prioritizing uncompromising safety in handling and logistics.

Primary Applications of Trimethylsilyl Chloride

Trimethylsilyl Chloride's unique reactivity and ability to introduce the trimethylsilyl group make it an indispensable reagent with extensive applications across various chemical synthesis pathways:

1. Protecting Group:

   One of its most widespread uses is as a protecting group for various functional groups in organic synthesis. It efficiently converts alcohols, phenols, carboxylic acids, and amines into their trimethylsilyl derivatives, which are often more stable, volatile, or unreactive to specific reagents, allowing for selective transformations elsewhere in the molecule.

2. Silylating Agent:

   It acts as a versatile silylating agent, introducing the trimethylsilyl group (Me₃Si– ) into organic molecules. This can modify physical properties, enhance solubility, or facilitate subsequent reactions.

3. Pharmaceutical Manufacturing:

   Trimethylsilyl Chloride is a crucial intermediate and reagent in the synthesis of numerous active pharmaceutical ingredients (APIs) and their precursors. Its role in protecting sensitive groups and enabling specific reactions is vital in complex drug synthesis routes.

4. Agrochemical Production:

   It is widely employed in the synthesis of various agrochemicals, including pesticides, herbicides, and plant growth regulators, where silylation plays a role in modifying reactivity or stability.

5. Analytical Chemistry:

   Used in analytical chemistry for derivatization, particularly to increase the volatility of polar compounds (like amino acids, sugars) for gas chromatography (GC) analysis, enabling their detection and quantification.

6. Production of Silicone Intermediates:

   Serves as a raw material or intermediate in the synthesis of other silicone compounds, including silanes, siloxanes, and specialty silicone polymers.

7. Catalyst and Reagent:

   In some reactions, it can function as a mild Lewis acid catalyst or as a source of chloride ions.

• Exceptional Purity & Consistent Quality: Our Trimethylsilyl Chloride is manufactured to stringent purity specifications, crucial for optimizing performance and selectivity in sensitive organic synthesis reactions, particularly in pharmaceutical and fine chemical production.

• Expert Technical & Safety Support: Our dedicated team of experienced chemists and highly trained safety specialists is readily available to offer comprehensive guidance on product application, stringent safe handling procedures, emergency response planning, and optimal storage conditions for Trimethylsilyl Chloride.

• Commitment to Quality & Responsible Stewardship: We adhere to the highest industry standards for quality management, environmental responsibility, and product stewardship across all our operations, ensuring peace of mind for our clients and the responsible management of hazardous chemicals.

section class="safety-storage">

Hazards Classification