4-Chlorobutyryl chloride

Basic Information

CAS No.	4635-59-0
EC No.	225-059-1
Linear Formula	Cl(CH2)3COCl
Molecular Weight	141.00
Appearance	Colorless to light yellow clear liquid
Melting Point	-47 °C
Boiling point	173-174 °C (lit.)
Density	1.26 g/mL at 25 °C (lit.)
Solubility	Reacts with water; soluble in common organic solvents (ether, chloroform, dichloromethane)
Storage Conditions	Keep in a tightly closed container in a cool, dry place under inert atmosphere. Protect from moisture and light.
Chemical Structure

Key Applications

• Organic synthesis intermediate: 4-Chlorobutyryl chloride serves as a reactive building block for acylation and introduction of the 4-chlorobutyl moiety in complex organic molecules.

• Fine chemical intermediate: It is utilized in the preparation of specialty fine chemicals requiring precise chloro-substituted acyl functionality.

• Pharmaceutical intermediate: The compound acts as a key precursor in the synthesis of pharmaceutical APIs such as fexofenadine and related derivatives.

• Laboratory research: Researchers employ it in exploratory synthetic studies and methodology development involving acid chloride chemistry.

• Process development: It facilitates route optimization and scale-up work in custom synthesis projects for complex organic targets.

• Consistent product quality: High purity specifications and consistent batch quality are ensured through routine analytical testing suitable for fine chemical sourcing.

• Flexible global supply: Flexible international shipping arrangements support laboratory scale, pilot scale and bulk procurement for global customers.

• SDS and COA support: Standard product documentation including SDS and COA is available upon request for sourcing, export and quality review.

• Packaging and technical service: Flexible packaging options in 25L/200L HDPE drum, moisture-protected together with responsive technical communication.