2-Chloromethyl-1,3-dioxolane

Basic Information

CAS No.	2568-30-1
EC No.	219-908-5
Linear Formula	ClCH2CH(OCH2CH2)O
Molecular Weight	122.55
Appearance	Colorless to light yellow clear liquid
Melting Point	Not available
Boiling point	157-158 °C (lit.)
Density	1.234 g/mL at 25 °C (lit.)
Solubility	Insoluble in water; soluble in common organic solvents (chloroform, ethyl acetate, ethanol)
Storage Conditions	Keep in a tightly closed container in a cool, dry place. Protect from light and moisture.
Chemical Structure

Key Applications

• Organic synthesis intermediate: 2-Chloromethyl-1,3-dioxolane serves as a masked chloroacetaldehyde building block for nucleophilic substitution and carbonyl transformations under mild conditions.

• Fine chemical intermediate: It is utilized in the preparation of specialty fine chemicals that require acetal-protected chloromethyl functionality.

• Pharmaceutical intermediate: The compound acts as a key precursor in the synthesis of pharmaceutical APIs including doxofylline and related derivatives.

• Laboratory research: Researchers employ it in exploratory synthetic studies and methodology development involving protected aldehydes.

• Process development: It facilitates route optimization and scale-up activities in custom synthesis projects for complex organic targets.

• Consistent product quality: Reliable material quality is supported by routine quality control to deliver batch consistency suitable for fine chemical sourcing.

• Flexible global supply: Supply support for laboratory scale, pilot scale and bulk procurement is ensured through established logistics channels.

• SDS and COA support: Documentation support for sourcing, export and quality review is provided with SDS and COA available upon request.

• Packaging and technical service: Flexible packaging options for sample, trial and bulk supply include 25L/200L HDPE drum, moisture-protected together with professional technical communication.