Pentaethylene glycol monomethyl ether

Pentaethylene glycol monomethyl ether (CAS 23778-52-1), also known as mPEG5-Alcohol or MeO-PEG5-OH, is a monodisperse methoxy-terminated polyethylene glycol derivative featuring a terminal hydroxyl group. This structure makes it a versatile intermediate for further functionalization in organic synthesis and bioconjugation applications.

Basic Information

CAS No.	23778-52-1
EC No.	Not available
Linear Formula	CH₃O(CH₂CH₂O)₄CH₂CH₂OH
Molecular Weight	252.31 g/mol
Appearance	Colorless to light yellow clear liquid
Melting Point	Not available (typical reference)
Boiling point	110 °C at 0.01 Torr (lit.)
Density	1.08 g/cm³
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage at -20°C or 2-8°C.
Chemical Structure

Key Applications

• Methoxy PEG intermediate: Serves as a defined methoxy-terminated PEG5 building block for further derivatization into amines, tosylates, or other functional PEG linkers.

• Fine chemical intermediate: Acts as a versatile reagent for introducing hydrophilic methoxy-PEG segments into complex organic molecules during specialty synthesis.

• Pharmaceutical intermediate: Employed in the preparation of PEGylated drug candidates and intermediates requiring a controlled hydrophilic spacer.

• Process development: Supports laboratory and pilot-scale efforts in optimizing synthetic routes that incorporate precise PEG derivatives.

• Laboratory research: Widely used in medicinal chemistry and bioconjugation research for developing functional PEG linkers and studying structure-property relationships.

• Consistent product quality: High-purity Pentaethylene glycol monomethyl ether is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Available in small laboratory quantities in sealed containers or sample bottles; larger volumes supplied in suitable HDPE drums. Customized liquid packaging options can be arranged based on specific requirements.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated place. Protect from moisture. Long-term storage recommended at -20°C or 2-8°C.

• Handling of opened containers: After opening, minimize exposure to air and moisture. Use the contents promptly and reseal the container tightly to maintain product integrity.

Safety and Handling

• General handling: Work in a well-ventilated area or chemical fume hood. Follow standard laboratory practices for handling organic compounds containing ether and alcohol functional groups.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before handling, storage, or transportation to ensure appropriate precautions are observed.