Dirhodium(II) Octanoate

Basic Information of Dirhodium(II) Octanoate

CAS No.	73482-96-9
EC No.	277-477-2
Chemical Formula	Rh₂(O₂CC₇H₁₅)₄
Molecular Weight	approx. 1076 g/mol
Appearance	Dark green to bluish-green powder or waxy solid
Odor	Slight carboxylic
Melting point	approx. 40–60 °C (softens)
Boiling point	Decomposes before boiling
Density	approx. 1.1–1.3 g/cm³
Solubility	Highly soluble in hydrocarbons, toluene, hexane, dichloromethane; insoluble in water
Nature (hazards)	May cause skin and eye irritation, harmful if swallowed or inhaled, toxic to aquatic life with long lasting effects
RIDADR	UN 3077, Environmentally hazardous substance, solid/liquid, n.o.s. (Dirhodium(II) octanoate), Class 9, Packing Group III
Chemical Structure

Primary Applications of Dirhodium(II) Octanoate

Dirhodium(II) Octanoate is the gold-standard Rh(II) catalyst for carbene and nitrene transfer reactions, delivering exceptional selectivity in complex molecule synthesis.

1. C–H Insertion & Functionalization
   Catalyzes highly selective intramolecular and intermolecular C–H insertion of diazo compounds, enabling efficient construction of C–C bonds in natural products and pharmaceutical intermediates.

2. Cyclopropanation of Alkenes
   Provides excellent diastereocontrol and enantioselectivity in cyclopropanation of olefins with diazoesters, delivering cyclopropane building blocks for drug discovery and agrochemicals.

3. Nitrene Transfer & Aziridination
   Enables stereoselective aziridination of alkenes and amidation of C–H bonds using nitrene sources, offering powerful strategies for nitrogen-containing heterocycles.

4. O–H & N–H Insertion
   Facilitates insertion into alcohols and amines to form ethers and amines, providing mild, selective routes to oxygenated and nitrogenated compounds.

5. Pharmaceutical & Natural Product Synthesis
   Widely applied in late-stage functionalization and key bond-forming steps of complex APIs and natural products, leveraging its high reactivity and functional group tolerance.

6. Catalyst Development & Asymmetric Catalysis
   Serves as a standard Rh(II) source for chiral ligand screening and development of enantioselective dirhodium catalysts in academic and industrial R&D.

• Superior Purity & Solubility
  Advanced quality controls ensure high Rh content, minimal impurities, and excellent solubility in non-polar solvents for maximum catalytic activity.

• Secure Precious Metal Sourcing
  Transparent, responsible rhodium procurement with inventory buffering to provide supply stability and competitive pricing.

• Technical Catalysis Support
  Dedicated specialists offer guidance on diazo/nitrene precursor selection, reaction optimization, enantioselectivity tuning, and scale-up for maximum efficiency.

• Comprehensive Regulatory Compliance
  Full COA, REACH, RoHS, and detailed SDS documentation to facilitate seamless integration into pharmaceutical and fine chemical operations.

• Sustainability & Recycling Programs
  Ethical sourcing practices and rhodium recovery/recycling programs aligned with ESG objectives and sustainable chemistry principles.

Hazards Classification

• GHS Classification: Skin Irritation (Category 2); Eye Irritation (Category 2A); Specific Target Organ Toxicity, Single Exposure (respiratory) (Category 3); Aquatic Chronic (Category 3)

• Hazard Statements: H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation; H413: May cause long lasting harmful effects to aquatic life

• UN Number: UN 3077

• Hazard Class: 9 (Miscellaneous dangerous substances and articles)

• Packing Group: III