Cyclopropyl bromide

Cyclopropyl bromide is a reactive alkyl halide widely utilized as a building block in organic synthesis. It enables efficient introduction of the cyclopropyl moiety into target molecules through substitution or organometallic reactions.

This specialty reagent supports the construction of complex structures commonly found in pharmaceutical candidates and advanced fine chemicals.

Basic Information

CAS No.	4333-56-6
EC No.	224-375-7
Linear Formula	C3H5Br
Molecular Weight	120.98
Appearance	Clear colorless to pale yellow liquid
Melting Point	Not available (typical reference)
Boiling point	69 °C (lit.)
Density	1.51 g/mL at 25 °C (lit.)
Solubility	Insoluble in water; soluble in common organic solvents
Storage Conditions	Store at 2–8 °C in a tightly closed container, protected from light and moisture
Chemical Structure

Key Applications

• Organic synthesis intermediate: Cyclopropyl bromide is used in alkylation and Grignard reactions to incorporate the cyclopropyl ring into organic frameworks.

• Pharmaceutical intermediate: Employed in the synthesis of cyclopropyl-substituted active pharmaceutical ingredients and drug candidates.

• Fine chemical intermediate: Supports production of specialty fine chemicals featuring strained-ring architectures.

• Laboratory research: Essential reagent for synthetic methodology studies and medicinal chemistry exploration.

• Process development: Aids route optimization and scale-up for processes requiring cyclopropyl building blocks.

• Consistent product quality: High purity specifications maintained through routine quality control and batch verification testing.

• Flexible global supply: Stable international logistics arrangements supporting laboratory, pilot, and production scale requirements.

• SDS and COA support: Standard SDS and COA documentation provided for regulatory compliance and customer quality assurance.

• Packaging and technical service: Tailored packaging in HDPE drums or lab-scale bottles with responsive technical assistance for liquid handling.