Tetramethyldisiloxane (TMDSO)

GTC-640

Linear Siloxanes

Tetramethyldisiloxane (TMDSO)

CAS No.
3277-26-7
Catalogue ID
GTC-640

Tetramethyldisiloxane (TMDSO), CAS 3277-26-7. Source-derived identification, physical data and applications are provided for catalogue reference; request the current specification, COA and SDS for the required grade.

Catalogue aliases / related identifiers

TMDSO; TMDS; DMDO; sym-Tetramethyldisiloxane; Dimethylsilyl ether; 1,3-Dihydrotetramethyldisiloxane; 1,1,3,3-Tetramethyldisiloxane; Disiloxane, 1,1,3,3-tetramethyl-

Supplied catalogue source: GTC-640 · Page 53

Reference data — confirm before ordering or use

The information below is a structured migration from the supplied catalogue snapshot. It is not a current product specification, COA or SDS. Confirm the actual supplier, grade, batch documents, classification, packing and destination requirements for your enquiry.

Tetramethyldisiloxane (TMDSO) is a crucial organosilicon compound with the chemical formula (CH₃)₂HSi-O-SiH(CH₃)₂. It presents as a clear, colorless liquid, characterized by low viscosity, high volatility, and excellent chemical stability. The unique aspect of TMDSO lies in its molecular structure, which contains two active silicon-hydrogen (Si-H) bonds. This feature makes it a versatile chemical intermediate, demonstrating superior performance in a wide range of reactions.


Basic Information of Tetramethyldisiloxane

CAS No.:3277-26-7
EC No.:221-906-4
Linear Formula:(CH₃)₂HSi-O-SiH(CH₃)₂
Molecular Weight:134.32
Appearance:Transparent Liquid
Melting Point:<-78°C
Boiling point:70-71 °C (lit.)
Density:0.76 g/mL at 25 °C (lit.)
Solubility:Soluble in Chloroform
Flash Point:14 °F
RIDADR:UN 2924 3/PG 2
Chemical Structure:Molecular Structure of Tetramethyldisiloxane

Applications of TMSO

Due to its distinctive chemical structure and reactivity, TMDSO plays a pivotal role in numerous industrial sectors and research applications:

  • Organosilicon Materials:

    • An essential monomer or cross-linking agent for hydrosilylation reactions, used in the synthesis of various organosilicon polymers, silicone rubbers, and silicone resins.

    • Utilized in the preparation of functional organosilicon materials with specialized properties.

  • Pharmaceutical and Agrochemical Intermediates:

    • Serves as an important silylating agent, used to protect or modify organic molecules containing hydroxyl, amino, and other functional groups.

    • Acts as a reducing agent or a reactant for specific reactions in drug synthesis.

  • Fine Chemicals:

    • Employed as a coupling agent to enhance interfacial adhesion between inorganic fillers and organic polymers.

    • Used as a selective reducing agent in certain organic synthesis reactions.

    • Can function as a diluent or solvent for specific systems.

  • Analytical Applications:

    • Can be used as a gas chromatography (GC) stationary phase for the separation and analysis of organic compounds.

    • Used as a reference substance or a solvent component in Nuclear Magnetic Resonance (NMR) spectroscopy.

  • Surface Treatment:

    • Applied for the hydrophobization of material surfaces, improving their water repellency.


  • Exceptional Quality: We commit to providing high-purity TMDSO, ensuring consistency and success in your experiments and production processes.

  • Reliable Supply: Consistent production capabilities and inventory ensure timely delivery, supporting your production schedules.

  • Expert Technical Support: Our professional team is readily available to provide product information and technical consultation.


Hazards Classification

  • GHS Classification: Flammable Liquid (GHS02), Exclamation Mark (GHS07)

  • Hazard Statements: Highly flammable liquid and vapor; may cause skin and eye irritation.

  • UN Number: UN 2924

  • Hazard Class: 3 (Flammable Liquids)

  • Packing Group: II

GHS02: Flammable pictogram
GHS02: Flammable
GHS07: Exclamation mark pictogram
GHS07: Exclamation mark
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